1. Akihabara Dennou Gumi (Cyberteam In Akihabara)
Genre: Shojo, Magical Girl, School Life, Mecha, Science Fiction, Romance
The magical girl story with a twist. Using the same concept as prince giving memorandum to the heroine, the heroine determined to find the prince. She found the companion and then battle the evil, however, the prince didn't what she seems to expect.
The Reason Why It is Unique: Magical Girl with Mecha Ability, Twisted Ending
Trademark: Deus, Patapie, Scene at the Tree where the Heroine meet the Prince.
2. Mirai Nikki (Future Diary)
Genre: Shonen, Time Paradox, Science-Fiction, Gore, Psychological, Drama, Survival Horror, Suspense
The story of obsessive self-proclaimed girlfriend to supposed hero couple boy. They being co-operated in game of death joined by other 10 candidate decided by a godly being in order to replaced the God itself.
The Reason Why It is Unique: Time Paradox, Complex Relationship and Brutal Murder, make the famous Yandere face.
Trademark: Yuno's Yandere Face
3. Shingeki No Kyojin (Attack On Titan)
Genre: Shonen, Gore, Action, Dark Fantasy, Dystopian, Tragedy
An action-adventure story in steampunk-industrial revolution setting. The group of giants had terrorized the mankind and so mankind had to hide behind the wall. 10000 years later, mankind start to fight back, but what lies beneath is not what they really seem. Is the giant at fault or humanity itself to be blame?
The Reason Why It is Unique: The Story had too many conspiracy, Berserk for shonen
Trademark: Spiderman-style flying fox, Super Clean Freak Levi, Coming Out from Titans Body
4. K
Genre: Shonen, Shojo, Science-Fiction, Supernatural
The supernatural story with historical twist set on near future. 12 kings with supernatural power have territory of their own, with their own clan. One day, a subordinate being kill by a king. The story unfold as many people trying to find the killer, while unravel the mystery behind the supernatural power of the king.
The Reason Why It is Unique: The secret unfold in each episode.
Trademark: Yatagami Kuroh's distortion power.
5. Ghost In The Shell (Kokaku Kidotai lit. Mobiled Armor Riot Police)
Genre: Seinen, Science-Fiction, Cyberpunk
The special force consist of cyborg, mecha and human trying to keep balance between robot and human. However, when technology takes over humanity's judgement, whom to blame?
The Reason Why It is Unique: Human Soul in Robot Shell, Psychology between Technology and Humanity, Inspiration for Matrix Movie
Trademark: Motoko Kusanagi falling into invinsible scene, jack in wire
6. Neon Genesis Evangelion (Shin Seiki Evangelion lit. Gospel of A New Century)
Genre: Shonen/Seinen, Science Fiction, Religious Theme, Apocalyptic Fiction, Mecha, Drama Psychological Thriller
The most controversial anime and manga, the story of science-fiction begin when a son was called by his father to join enforcement to battle alien from nowhere. The secret unfold between the relationship of father-son, friends and lover as they battle against their own source of existence.
The Reason Why It is Unique: Complex Relationship, Religion-theme anime, Creating Tsundere and Dandere type of character, sex symbol.
Trademark: Cross-shaped explosion, Shinji's terrifying and angry expression, Tsundere and Dandere, Bandaged Woman, Dummy Plug, Voice Only Platform
7. Revolution Girl Utena (Shojo Kakumei Utena)
Genre: Shojo, Magical Girl, School Life, Surrealism, Yuri
The surrealism drama with Takarazuka-style presentation, tells about a girl who want to become a prince, and in order to protect her dream, she must battle many duelist which if she win, she possess the power to revolutionized the world.
The Reason Why It is Unique: Takarazuka-styled animation, Unexpected Moment, Surrealism Surrounding and Setting, Feminism, Base of all Yuri/Shojo/Magical Girl typical story.
Trademark: Takarazuka-styled animation, Drawing sword from body, Destroying Rose Bosom in a duel, Theater Style Soundtrack
8. Shitai O Arau (Corpse Washer)
Genre: Seinen, Hentai, Guro, Inflation, Necrophilia
The most erotic, gore and brutal hentai anime, the story tells about a medical student who want to become a doctor, but had no money. He had to take another closest job, as the corpse washer. None that he known, all that he sees is just an illusion, and he is actually already dead and being revived to involve in brutal experiment test as guinea pig. (Based on erotic visual novel by same name)
The Reason Why It is Unique: Using excessive of flashing disturbing image, Using Realistic Illustration for Corpse
Trademark: None
9. Fullmetal Alchemist (Hagane No Renkitjutsushi)
Genre: Shonen, Steampunk, Alchemy, Science Fantasy
The steampunk story about a brother who lost everything that important to them, and hoping by finding a magical stone, they able to retrieve their belonging back. However, what lies behind the stone is a horrifying truth, that actually shape and decide the fate of them and their world.
The Reason Why It is Unique: The First Anime that tell about alchemy.
Trademark: Clapping Hand that make alchemy, Shortie Joke, Minimal of Hair Color, Armor Character
10. High School of The Dead
Genre: Shonen, Post-Apocalyptic, Zombie, Horror, Harem
The typical high-school life become tragedy and horrifying, as 90% population of the world is infected by virus and become zombie. The group of survival high-schooler must face the danger of the zombie and travel to the other side of the world in hoping to get a cure or search rescue. But the truth might devastated their hope as the world is no longer like in their memories.
The Reason Why It is Unique: The First Anime that have zombie theme.
Trademark: Shooting Zombie while using boob as shock resistance
There are so many more memorable anime but this 10 that I think so far had made into breakthrough in anime history.